Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling
نویسندگان
چکیده
منابع مشابه
Cellular responses to extracellular guidance cues.
Extracellular guidance cues have a key role in orchestrating cell behaviour. They can take many forms, including soluble and cell-bound ligands (proteins, lipids, peptides or small molecules) and insoluble matrix substrates, but to act as guidance cues, they must be presented to the cell in a spatially restricted manner. Cells that recognize such cues respond by activating intracellular signal ...
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Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta superfamily that exert their effects via type I and type II serine threonine kinase receptors and the SMAD intracellular signaling pathway to regulate diverse biologic processes. Recently, we discovered that the repulsive guidance molecule (RGM) family, including RGMA, RGMB, and RGMC/hemojuvelin (HJV), functio...
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Laboratory of Ophthalmology and Visual Science, Catholic Research Institutes of Medical Sciences, Korean Eye Tissue and Gene Bank Related to Blindness, College of Medicine, The Catholic University of Korea, Seoul, Korea. Running title: Smad3 regulates RhoA via NET1 in TGF-1-induced cells Address correspondence to: Choun-Ki Joo, Laboratory of Ophthalmology and Visual Science, Catholic Research ...
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anism would thus be a new way to form a tube. As the generation of the lumen and of the tube itself requires the apparition of an apical domain, we decided to investigate how part of the lateral domain becomes apical. Our first results, using transgenes driven by brachyury regulating sequences, show that several proteins classically involved in antero-posterior and planar polarities could be in...
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Nerve growth factor (NGF) and semaphorin3A (Sema3A) are guidance cues found in pathways and targets of developing dorsal root ganglia (DRG) neurons. DRG growth cone motility is regulated by cytoplasmic signaling triggered by these molecules. We investigated interactions of NGF and Sema3A in modulating growth cone behaviors of axons extended from E7 chick embryo DRGs. Axons extending in collagen...
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ژورنال
عنوان ژورنال: Cell
سال: 2021
ISSN: 0092-8674
DOI: 10.1016/j.cell.2021.02.045